VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma

@article{Maharaj2008VEGFAT,
  title={VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma},
  author={Arindel S. R. Maharaj and Tony E. Walshe and Magali Saint-Geniez and Shivalingappa Venkatesha and Angel E. Maldonado and N Himes and Kabir S. Matharu and Siddharth Karumanchi and Patricia A D'Amore},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={491 - 501}
}
Although the role of vascular endothelial growth factor (VEGF) in developmental and pathological angiogenesis is well established, its function in the adult is less clear. Similarly, although transforming growth factor (TGF) beta is involved in angiogenesis, presumably by mediating capillary (endothelial cell [EC]) stability, its involvement in quiescent vasculature is virtually uninvestigated. Given the neurological findings in patients treated with VEGF-neutralizing therapy (bevacizumab) and… CONTINUE READING

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