VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma

  title={VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma},
  author={Arindel S. R. Maharaj and Tony E. Walshe and Magali Saint-Geniez and Shivalingappa Venkatesha and Angel E. Maldonado and N Himes and Kabir S. Matharu and Siddharth Karumanchi and Patricia A D'Amore},
  journal={The Journal of Experimental Medicine},
  pages={491 - 501}
Although the role of vascular endothelial growth factor (VEGF) in developmental and pathological angiogenesis is well established, its function in the adult is less clear. Similarly, although transforming growth factor (TGF) beta is involved in angiogenesis, presumably by mediating capillary (endothelial cell [EC]) stability, its involvement in quiescent vasculature is virtually uninvestigated. Given the neurological findings in patients treated with VEGF-neutralizing therapy (bevacizumab) and… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 69 extracted citations

VEGF: A potential target for hydrocephalus

Cell and Tissue Research • 2014
View 6 Excerpts
Highly Influenced

Anti-angiogenic therapy: adapting strategies to overcome resistant tumors.

Journal of cellular biochemistry • 2010
View 3 Excerpts
Highly Influenced

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 7 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 57 references

Molecular mechanisms of VEGF - A action during tissue repair

S. A. Eming
Development . • 2006

Similar Papers

Loading similar papers…