VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.

@article{Rudge2007VEGFTC,
  title={VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.},
  author={John S. Rudge and Jocelyn Holash and Donna Hylton and Michelle Russell and Shelly Jiang and R. M. Leidich and Nicholas Papadopoulos and Erica A. Pyles and Al Torri and Stanley J. Wiegand and Gavin Thurston and Neil Stahl and George D. Yancopoulos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 47},
  pages={18363-70}
}
VEGF is the best characterized mediator of tumor angiogenesis. Anti-VEGF agents have recently demonstrated impressive efficacy in human cancer trials, but the optimal dosing of such agents must still be determined empirically, because biomarkers to guide dosing have yet to be established. The widely accepted (but unverified) assumption that VEGF production… CONTINUE READING
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