VEGF Signaling through Neuropilin 1 Guides Commissural Axon Crossing at the Optic Chiasm

Abstract

During development, the axons of retinal ganglion cell (RGC) neurons must decide whether to cross or avoid the midline at the optic chiasm to project to targets on both sides of the brain. By combining genetic analyses with in vitro assays, we show that neuropilin 1 (NRP1) promotes contralateral RGC projection in mammals. Unexpectedly, the NRP1 ligand… (More)
DOI: 10.1016/j.neuron.2011.02.052

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