VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors.

@article{Mattila2002VEGFCIL,
  title={VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors.},
  author={Mirjami Mattila and Johanna K. Ruohola and Terhi Karpanen and David G Jackson and Kari Alitalo and Pirkko L. H{\"a}rk{\"o}nen},
  journal={International journal of cancer},
  year={2002},
  volume={98 6},
  pages={
          946-51
        }
}
The spread of cancer cells to regional lymph nodes through the lymphatic system is the first step in the dissemination of breast cancer. In several human cancers including those of the breast and prostate, the expression of vascular endothelial growth factor C (VEGF-C) is associated with lymph node metastasis. Our study was undertaken to evaluate the effect of VEGF-C on metastasis of poorly invasive, estrogen dependent human MCF-7 breast cancer cells. MCF-7 breast cancer cells transfected with… CONTINUE READING

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