VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway

@article{Kumar2011VEGFCDR,
  title={VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway},
  author={B. V. N. R Siva Kumar and Shailaja A. Chile and Kriti B. Ray and G. E. C. Vidyadhar Reddy and Murali K. Addepalli and A. S. Manoj Kumar and Venkata Ramana and Vikram Rajagopal},
  journal={Angiogenesis},
  year={2011},
  volume={14},
  pages={371-380}
}
Vascular angiogenesis is regulated by a number of cytokines of which vascular endothelial growth factor (VEGF)-A/and its receptor vascular endothelial growth factor receptor 2 (VEGFR2) play an indisputable role. Similarly lymphangiogenesis is regulated by VEGF-C and its receptor VEGFR3. Currently for treating vasculogenesis diseases such as proliferative retinopathies and cancer, a number of anti-VEGF-A therapies are approved for clinical use. Although clinical efficacies achieved are… CONTINUE READING
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