VEGF-C and TGF-β reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes

@inproceedings{Igarashi2016VEGFCAT,
  title={VEGF-C and TGF-β reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes},
  author={Yasuyuki Igarashi and Naoyuki Chosa and Shunsuke Sawada and Hisatomo Kondo and Takashi Yaegashi and Akira Ishisaki},
  booktitle={International journal of molecular medicine},
  year={2016}
}
The direction of mesenchymal stem cell (MSC) differentiation is regulated by stimulation with various growth factors and cytokines. We recently established MSC lines, [transforming growth factor-β (TGF-β)-responsive SG‑2 cells, bone morphogenetic protein (BMP)-responsive SG‑3 cells, and TGF-β/BMP-non-responsive SG‑5 cells], derived from the bone marrow of green fluorescent protein-transgenic mice. In this study, to compare gene expression profiles in these MSC lines, we used DNA microarray… CONTINUE READING
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