VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.

@article{Zhang2008VEGFCAL,
  title={VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.},
  author={Qian Zhang and Ruolin Guo and Yan Lu and Lan Zhao and Quan Zhou and Edward M Schwarz and Junji Huang and Di Chen and Z N Jin and Brendan F. Boyce and Lianping Xing},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 19},
  pages={13491-9}
}
Osteoclasts are bone-resorbing cells, but they also secrete and respond to cytokines. Here, we test the hypothesis that osteoclasts secrete the lymphatic growth factor, VEGF-C, to increase their resorptive activity. Osteoclasts and osteoclast precursors were generated by culturing splenocytes with macrophage colony-stimulating factor and RANKL from wild-type, NF-kappaBp50(-/-)/p52(-/-), and Src(-/-) mice. Expression of VEGFs was measured by real time reverse transcription-PCR, Western blotting… CONTINUE READING