VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

  title={VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart},
  author={Riikka Kivel{\"a} and Maija Bry and Marius Robert Robciuc and Markus R{\"a}s{\"a}nen and Miia Taavitsainen and Johanna M. U. Silvola and Antti Saraste and Juha J Hulmi and Andrey Anisimov and Mikko I M{\"a}yr{\"a}np{\"a}{\"a} and Jan H. N. Lindeman and Lauri Eklund and Sanna Hellberg and Ruslan Hlushchuk and Zhen W. Zhuang and Michael Simons and Valentin Djonov and Juhani Knuuti and Eero M. A. Mervaala and Kari Alitalo},
  booktitle={EMBO molecular medicine},
Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain- and loss-of function models to elucidate the effects and mechanisms of action of vascular endothelial growth factor-B (VEGF-B) in the heart. A cardiomyocyte-specific VEGF-B transgene induced an expanded coronary arterial tree and reprogramming of cardiomyocyte metabolism. This was associated with protection against myocardial infarction and preservation of mitochondrial complex I function upon… CONTINUE READING
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