VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro.

@article{BeazleyLong2013VEGFA165bIA,
  title={VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro.},
  author={Nicholas Beazley-Long and Jing Hua and Thomas Jehle and Richard P Hulse and Rick Dersch and Christina Lehrling and Heather Bevan and Yan Qiu and Wolf Alexander Lagr{\`e}ze and David Wynick and Amanda Jane Churchill and Patrick Gavin Kehoe and Steve Harper and David W Bates and Lucy F Donaldson},
  journal={The American journal of pathology},
  year={2013},
  volume={183 3},
  pages={918-29}
}
Vascular endothelial growth factor (VEGF) A is generated as two isoform families by alternative RNA splicing, represented by VEGF-A165a and VEGF-A165b. These isoforms have opposing actions on vascular permeability, angiogenesis, and vasodilatation. The proangiogenic VEGF-A165a isoform is neuroprotective in hippocampal, dorsal root ganglia, and retinal neurons, but its propermeability, vasodilatatory, and angiogenic properties limit its therapeutic usefulness. In contrast, a neuroprotective… CONTINUE READING

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