VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes.

Abstract

Lymphangiogenesis is involved in tumor cell metastasis and plays a major role in chronic inflammatory disorders. To investigate the role of lymphangiogenesis in inflammation, we induced and maintained delayed-type hypersensitivity (DTH) reactions in the ears of mice and then analyzed the resulting lymphangiogenesis in the inflamed tissue and draining lymph… (More)
DOI: 10.1182/blood-2007-01-066811

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