VEGF-A levels in bevacizumab-treated breast cancer patients: a systematic review and meta-analysis

@article{Santos2015VEGFALI,
  title={VEGF-A levels in bevacizumab-treated breast cancer patients: a systematic review and meta-analysis},
  author={Lucas Vieira dos Santos and Marcelo Rocha Sousa Cruz and Gilberto de Lima Lopes and Jo{\~a}o Paulo da Silveira Nogueira Lima},
  journal={Breast Cancer Research and Treatment},
  year={2015},
  volume={151},
  pages={481-489}
}
Bevacizumab may improve outcomes of patients with breast cancer, but the absence of an established biomarker hampers patient selection and researchers´ ability to demonstrate a clear survival benefit. Its putative target, circulating VEGF-A, emerged as the main candidate and we sought to identify the relationship between VEGF-A levels and outcomes through systematic review. We searched electronic databases and meeting proceedings for randomized controlled trials (RCTs) comparing the addition of… CONTINUE READING
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