VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis

@inproceedings{Fearnley2016VEGFAIP,
  title={VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis},
  author={Gareth W. Fearnley and Gina A. Smith and Izma Abdul-Zani and Nadira Yuldasheva and Nadeem A. Mughal and Shervanthi Homer-Vanniasinkam and Mark T Kearney and Ian C. Zachary and Darren Charles Tomlinson and Michael A. Harrison and Stephen B. Wheatcroft and Sreenivasan Ponnambalam},
  booktitle={Biology open},
  year={2016}
}
Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can elicit differential signal transduction and endothelial responses. However, it is unclear how such cellular responses are controlled by isoform-specific VEGF-A-VEGFR2 complexes. Increasingly, there is the realization that the membrane trafficking of… CONTINUE READING
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