VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis

  title={VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis},
  author={Gareth W. Fearnley and Gina A. Smith and Izma Abdul-Zani and Nadira Yuldasheva and Nadeem A. Mughal and Shervanthi Homer-Vanniasinkam and Mark T Kearney and Ian C. Zachary and Darren Charles Tomlinson and Michael A. Harrison and Stephen B. Wheatcroft and Sreenivasan Ponnambalam},
  booktitle={Biology open},
Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can elicit differential signal transduction and endothelial responses. However, it is unclear how such cellular responses are controlled by isoform-specific VEGF-A-VEGFR2 complexes. Increasingly, there is the realization that the membrane trafficking of… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

International journal of molecular sciences • 2018
View 7 Excerpts
Highly Influenced

A novel design of non-contact GMR displacement measurement system based on neural network

2017 IEEE International Conference on Information and Automation (ICIA) • 2017
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 71 references

Spatial regulation of VEGF receptor endocytosis in angiogenesis

Nature Cell Biology • 2013
View 4 Excerpts
Highly Influenced

aortic ring assay to study angiogenesis

K. Ballmer-Hofer, A. E. Andersson, L. E. Ratcliffe, P. Berger
Nat. Protoc • 2011
View 5 Excerpts
Highly Influenced

VEGF-A splicing: the key to anti-angiogenic therapeutics?

Nature Reviews Cancer • 2008
View 19 Excerpts
Highly Influenced

Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting.

The Journal of biological chemistry • 2007
View 20 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…