VEGF/VEGFR pathway inhibitors as anti-angiogenic agents: present and future.

@article{Sharma2011VEGFVEGFRPI,
  title={VEGF/VEGFR pathway inhibitors as anti-angiogenic agents: present and future.},
  author={Pooja Sapra Sharma and Rajendra N. Sharma and Tulika Tyagi},
  journal={Current cancer drug targets},
  year={2011},
  volume={11 5},
  pages={624-53}
}
Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a central role in the process of tumor growth and metastasis. The proliferation of endothelium and formation of new blood vessels further the size of solid tumors. It is expected that blocking angiogenesis will be an efficient therapeutic approach against many tumor types. The key signaling system that regulates proliferation and migration of endothelial cells are vascular endothelium growth factor (VEGF) and their… CONTINUE READING