VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury.

@article{Guo2011VEGFBA,
  title={VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury.},
  author={Qiang Guo and Jun Jin and Jason X-J Yuan and Amy S. Zeifman and Jiwan Chen and Bo Shen and Jianan Huang},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={413 4},
  pages={630-6}
}
Molecular mechanisms of acute lung injury (ALI) are poorly defined. Our previous study demonstrated that recombinant angiopoietin-1 (Ang1) can protect against oleic acid (OA) induced ALI at an early stage. The purpose of this study was to elucidate whether vascular endothelial growth factor (VEGF), Bcl-2, and Bad, phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) play any role in the protective mechanism of recombinant Ang1 in OA-induced ALI. All BALB/C mice were administered a single… CONTINUE READING
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