VEGF(165), but not VEGF(189), stimulates vasculogenesis and bone marrow cell migration into Ewing's sarcoma tumors in vivo.

@article{Zhou2007VEGF165BN,
  title={VEGF(165), but not VEGF(189), stimulates vasculogenesis and bone marrow cell migration into Ewing's sarcoma tumors in vivo.},
  author={Zhichao Zhou and K. Raghunandan Reddy and Hui Jie Guan and Eugenie S Kleinerman},
  journal={Molecular cancer research : MCR},
  year={2007},
  volume={5 11},
  pages={1125-32}
}
We previously showed that bone marrow stem cells participate in the tumor vessel expansion that supports the growth of Ewing's sarcoma tumors in vivo. The purpose of this study was to determine the relative importance of two isoforms of vascular endothelial growth factor (VEGF) in tumor vessel expansion and recruitment of bone marrow-derived cells during tumor growth. We injected VEGF(165)-siRNA-transfected cells (TCsi/7-1), control siRNA-transfected cells (TC/si-control), or TC71 parental… CONTINUE READING

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