VE-cadherin Links tRNA Synthetase Cytokine to Anti-angiogenic Function*

  title={VE-cadherin Links tRNA Synthetase Cytokine to Anti-angiogenic Function*},
  author={Eleni Tzima and John S. Reader and Mohamad Irani-Tehrani and Karla Lynn Ewalt and Martin Alexander Schwartz and Paul R. Schimmel},
  journal={Journal of Biological Chemistry},
  pages={2405 - 2408}
A natural fragment of an enzyme that catalyzes the first step of protein synthesis—human tryptophanyl-tRNA synthetase (T2-TrpRS) has potent anti-angiogenic activity. A cellular receptor through which T2-TrpRS exerts its anti-angiogenic activity has not previously been identified. Here T2-TrpRS was shown to bind at intercellular junctions of endothelial cells (ECs). Using genetic knock-outs, binding was established to depend on VE-cadherin, a calcium-dependent adhesion molecule, which is… 

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