VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells

@inproceedings{AragonSanabria2017VECadherinDA,
  title={VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells},
  author={Virginia Aragon-Sanabria and Steven E. Pohler and Vikram Jayraj Eswar and Matthew Bierowski and Esther W. Gomez and Cheng Dong},
  booktitle={Scientific reports},
  year={2017}
}
During metastasis, breakdown of the endothelial barrier is critical for tumor cell extravasation through blood vessel walls and is mediated by a combination of tumor secreted soluble factors and receptor-ligand interactions. However, a complete mechanism governing tumor cell transendothelial migration remains unclear. Here, we investigate the roles of tumor-associated signals in regulating endothelial cell contractility and adherens junction disassembly leading to endothelial barrier breakdown… CONTINUE READING
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