VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression

  title={VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression},
  author={Seung Hyun Han and Jun Ho Jeon and Hyang Ran Ju and Uhee Jung and Kun Young Kim and Hyang Sook Yoo and Young Ho Lee and Kyu Sang Song and Ho Myeung Hwang and Yoon Sook Na and Young Yang and Kee Nyung Lee and Inpyo Choi},
Vitamin D3 upregulated protein 1 (VDUP1) is a 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) upregulated protein, and it is induced by various stresses. In human tumor tissues, VDUP1 expression was downregulated. Upon stimulation by growth-inhibitory signals such as TGF-β1 and 1,25(OH)2D3, its expression was rapidly upregulated as the cell growth was retarded. The transfection of VDUP1 in tumor cells reduced cell growth. The VDUP1 expression was also increased when the cell-cycle progression was… CONTINUE READING
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