VDAC1 functions in Ca2+ homeostasis and cell life and death in health and disease.

@article{ShoshanBarmatz2018VDAC1FI,
  title={VDAC1 functions in Ca2+ homeostasis and cell life and death in health and disease.},
  author={Varda Shoshan-Barmatz and Yakov Krelin and Anna Shteinfer-Kuzmine},
  journal={Cell calcium},
  year={2018},
  volume={69},
  pages={
          81-100
        }
}
In the outer mitochondrial membrane (OMM), the voltage-dependent anion channel 1 (VDAC1) serves as a mitochondrial gatekeeper, controlling the metabolic and energy cross-talk between mitochondria and the rest of the cell. VDAC1 also functions in cellular Ca2+ homeostasis by transporting Ca2+ in and out of mitochondria. VDAC1 has also been recognized as a key protein in mitochondria-mediated apoptosis, contributing to the release of apoptotic proteins located in the inter-membranal space (IMS… CONTINUE READING
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