VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis.

@article{ShoshanBarmatz2017VDAC1AA,
  title={VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis.},
  author={Varda Shoshan-Barmatz and Yakov Krelin and Quan Chen},
  journal={Current medicinal chemistry},
  year={2017},
  volume={24 40},
  pages={
          4435-4446
        }
}
BACKGROUND The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane protein, functions as a mitochondrial governor, controlling transport of metabolites in and out of the mitochondria and energy production, while also coordinating glycolysis and oxidative phosphorylation. VDAC1 plays a key role in mitochondria-mediated apoptosis by functioning in the release of apoptotic proteins located in the inter-membranal space and due to its association with pro- and anti-apoptotic… CONTINUE READING

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