VDAC regulation: role of cytosolic proteins and mitochondrial lipids.

  title={VDAC regulation: role of cytosolic proteins and mitochondrial lipids.},
  author={Tatiana K. Rostovtseva and Sergey M. Bezrukov},
  journal={Journal of bioenergetics and biomembranes},
  volume={40 3},
It was recently asserted that the voltage-dependent anion channel (VDAC) serves as a global regulator, or governor, of mitochondrial function (Lemasters and Holmuhamedov, Biochim Biophys Acta 1762:181-190, 2006). Indeed, VDAC, positioned on the interface between mitochondria and the cytosol (Colombini, Mol Cell Biochem 256:107-115, 2004), is at the control point of mitochondria life and death. This large channel plays the role of a "switch" that defines in which direction mitochondria will go… CONTINUE READING


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