VDAC–Tubulin, an Anti-Warburg Pro-Oxidant Switch

  title={VDAC–Tubulin, an Anti-Warburg Pro-Oxidant Switch},
  author={Eduardo N. Maldonado},
  booktitle={Front. Oncol.},
Aerobic enhanced glycolysis characterizes the Warburg phenotype. In cancer cells, suppression of mitochondrial metabolism contributes to maintain a low ATP/ADP ratio that favors glycolysis. We propose that the voltage-dependent anion channel (VDAC) located in the mitochondrial outer membrane is a metabolic link between glycolysis and oxidative… CONTINUE READING