VCP Is an Integral Component of a Novel Feedback Mechanism that Controls Intracellular Localization of Catalase and H2O2 Levels

@inproceedings{Murakami2013VCPIA,
  title={VCP Is an Integral Component of a Novel Feedback Mechanism that Controls Intracellular Localization of Catalase and H2O2 Levels},
  author={Katsuhiro Murakami and Yuzuru Ichinohe and Masaaki Koike and Norio Sasaoka and Shun-ichiro Iemura and Tohru Natsume and Akira Kakizuka},
  booktitle={PloS one},
  year={2013}
}
  • Katsuhiro Murakami, Yuzuru Ichinohe, +4 authors Akira Kakizuka
  • Published in PloS one 2013
  • Biology, Medicine
  • Catalase is a key antioxidant enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2) to water and oxygen, and it appears to shuttle between the cytoplasm and peroxisome via unknown mechanisms. Valosin-containing protein (VCP) belongs to the AAA class of ATPases and is involved in diverse cellular functions, e.g. cell cycle and protein degradation, etc. Here we show that VCP and PEX19, a protein essential for peroxisome biogenesis, interact with each other. Knockdown of either VCP… CONTINUE READING

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    Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.

    VIEW 2 EXCERPTS

    p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.

    VIEW 1 EXCERPT