VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis.

  title={VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis.},
  author={S{\'e}bastien Serres and Silvy Mardiguian and Sandra J. Campbell and Martina A. McAteer and Asim Munir Akhtar and Alexandre Krapitchev and Robin Choudhury and Daniel C. Anthony and Nicola R. Sibson},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={25 12},
Diagnosis of multiple sclerosis (MS) currently requires lesion identification by gadolinium (Gd)-enhanced or T(2)-weighted magnetic resonance imaging (MRI). However, these methods only identify late-stage pathology associated with blood-brain barrier breakdown. There is a growing belief that more widespread, but currently undetectable, pathology is present in the MS brain. We have previously demonstrated that an anti-VCAM-1 antibody conjugated to microparticles of iron oxide (VCAM-MPIO) enables… CONTINUE READING
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