VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis.

@article{Sans1999VCAM1AI,
  title={VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis.},
  author={Miquel Sans and Juli{\'a}n Pan{\'e}s and Esther Ardite and Jose Ignasi Elizalde and Yolanda Arce and Monserrat Elena and Antonio Palac{\'i}n and Jos{\'e} C Fern{\'a}ndez-Checa and Donald C. Anderson and Roy Lobb and Josep Mar{\'i}a Piqu{\'e}},
  journal={Gastroenterology},
  year={1999},
  volume={116 4},
  pages={874-83}
}
BACKGROUND & AIMS The molecular mechanisms responsible for leukocyte recruitment in experimental colitis are poorly understood. The aims of this study were to measure expression of endothelial intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) and to determine their role in leukocyte recruitment in experimental colitis. METHODS Rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis and control rats were studied 1, 7, or 21 days after treatment… CONTINUE READING
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