VBP15, a Novel Anti-Inflammatory, is Effective at Reducing the Severity of Murine Experimental Autoimmune Encephalomyelitis

@article{Dillingham2014VBP15AN,
  title={VBP15, a Novel Anti-Inflammatory, is Effective at Reducing the Severity of Murine Experimental Autoimmune Encephalomyelitis},
  author={Blythe C. Dillingham and Susan Knoblach and Gina M. Many and Brennan T. Harmon and Amanda M. Mullen and Christopher R. Heier and Luca Bello and John M. McCall and Eric P. Hoffman and Edward M. Connor and Kanneboyina Nagaraju and Erica K. M. Reeves and Jesse M. Damsker},
  journal={Cellular and Molecular Neurobiology},
  year={2014},
  volume={35},
  pages={377-387}
}
Multiple sclerosis is a chronic disease of the central nervous system characterized by an autoimmune inflammatory reaction that leads to axonal demyelination and tissue damage. Glucocorticoids, such as prednisolone, are effective in the treatment of multiple sclerosis in large part due to their ability to inhibit pro-inflammatory pathways (e.g., NFκB). However, despite their effectiveness, long-term treatment is limited by adverse side effects. VBP15 is a recently described compound synthesized… CONTINUE READING

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