VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria.

@article{Hviid2007VAR2CSAAP,
  title={VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria.},
  author={Lars Hviid and Ali Salanti},
  journal={Parasitology},
  year={2007},
  volume={134 Pt 13},
  pages={1871-6}
}
People living in areas with stable transmission of P. falciparum parasites acquire protective immunity to malaria over a number of years and following multiple disease episodes. Immunity acquired this way is mediated by IgG with specificity for parasite-encoded, clonally variant surface antigens (VSA) on the surface of infected erythrocytes (IEs). However, women in endemic areas become susceptible to P. falciparum infection when they become pregnant, particularly for the first time, regardless… CONTINUE READING