VALIDATION OF NEUROTENSIN TETRA-BRANCHED PEPTIDES AS TUMOR TARGETING AGENTS IN PANCREAS, COLON AND BLADDER CARCINOMA

@inproceedings{Ravenni2012VALIDATIONON,
  title={VALIDATION OF NEUROTENSIN TETRA-BRANCHED PEPTIDES AS TUMOR TARGETING AGENTS IN PANCREAS, COLON AND BLADDER CARCINOMA},
  author={Niccol{\`o} Ravenni and Barbara Lelli and Jlenia Brunetti and Chiara Falciani and Lorenzo Depau and Lapo Bencini and Andrea Minervini and Raffaele Moretti and Marco Carini and Luisa Bracci},
  year={2012}
}
The identification of new tumor targeting agents, which might allow either cancer cell tracing or ther- apy, is a crucial issue in cancer research. Membrane receptors for endogenous peptides such as neu- rotensin, somatostatin, bombesin and many others are over-expressed in different human cancers and could therefore be targeted as tumor-specific antigens. In the meantime the extremely short half-life of pep- tides impeded their development for effective pep- tide-based tumor targeting… CONTINUE READING