V599EB-RAF is an oncogene in melanocytes.

  title={V599EB-RAF is an oncogene in melanocytes.},
  author={Claudia Wellbrock and Lesley M Ogilvie and Douglas Hedley and Maria Karasarides and Jan M. Martin and Dan Niculescu-Duvaz and Caroline J. Springer and Richard Marais},
  journal={Cancer research},
  volume={64 7},
The oncogenic version of B-RAF, (V599E)B-RAF, is found in approximately 70% of human melanomas. However, the role that this oncogene plays in melanoma is unclear because (V559E)B-RAF is also found in approximately 80% of benign nevi. We have examined the role of oncogenic B-RAF in the early stages of melanoma by expressing (V599E)B-RAF in cultured melanocytes. In these cells, (V599E)B-RAF induced constitutive mitogen activated ERK-activating kinase (MEK) and extracellular signal-regulated… CONTINUE READING