V599EB-RAF is an oncogene in melanocytes.


The oncogenic version of B-RAF, (V599E)B-RAF, is found in approximately 70% of human melanomas. However, the role that this oncogene plays in melanoma is unclear because (V559E)B-RAF is also found in approximately 80% of benign nevi. We have examined the role of oncogenic B-RAF in the early stages of melanoma by expressing (V599E)B-RAF in cultured… (More)


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@article{Wellbrock2004V599EBRAFIA, title={V599EB-RAF is an oncogene in melanocytes.}, author={Claudia Wellbrock and Lesley M Ogilvie and Douglas Hedley and Maria Karasarides and Jan Martin and Dan Niculescu-Duvaz and Caroline J. Springer and Richard Marais}, journal={Cancer research}, year={2004}, volume={64 7}, pages={2338-42} }