V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift

@article{Takeda1995VsrcKS,
  title={V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift},
  author={H Takeda and Akira Nagafuchi and S Yonemura and J Behrens and W Birchmeier and S Tsukita},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={131},
  pages={1839 - 1847}
}
  • H Takeda, Akira Nagafuchi, +3 authors S Tsukita
  • Published 1995 in The Journal of cell biology
The elevation of tyrosine phosphorylation level is thought to induce the dysfunction of cadherin through the tyrosine phosphorylation of beta catenin. We evaluated this assumption using two cell lines. First, using temperature-sensitive v-src-transfected MDCK cells, we analyzed the modulation of cadherin-based cell adhesion by tyrosine phosphorylation. Cell aggregation and dissociation assays at nonpermissive and permissive temperatures indicated that elevation of the tyrosine phosphorylation… CONTINUE READING
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