V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice.

@article{Eilat1988VRS,
  title={V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice.},
  author={Dan Eilat and Donna M Webster and Anthony Robert Rees},
  journal={Journal of immunology},
  year={1988},
  volume={141 5},
  pages={
          1745-53
        }
}
The V region sequences of two anti-DNA (A52, D42) and two anti-RNA (D44, D444) autoantibodies, derived from lupus prone NZB/NZW F1 female mice, were determined by mRNA sequencing. The sequences had the following features: 1) there was no clear sequence relationship between anti-DNA and anti-RNA antibodies; 2) there were no major similarities between any of the L chain sequences and each VL gene segment belonged to a different mouse VK subgroup; 3) the H chains of the two anti-RNA antibodies… CONTINUE READING

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