V beta-specific stimulation of human T cells by staphylococcal toxins.

@article{Kappler1989VBS,
  title={V beta-specific stimulation of human T cells by staphylococcal toxins.},
  author={John W Kappler and Brian L. Kotzin and Lanny Herron and Erwin W. Gelfand and Robert D. Bigler and Arthur W. Boylston and Stefan Carrel and David N. Posnett and Yongwon Choi and Philippa Marrack},
  journal={Science},
  year={1989},
  volume={244 4906},
  pages={
          811-3
        }
}
The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell stimulants. They do not, however, stimulate all T cells. On the contrary, each toxin reacts with human T cells bearing particular V beta sequences as part of their receptors for major histocompatibility complex protein-associated antigen. The specificity of these toxins for V beta s puts them in the recently described class of superantigens… CONTINUE READING
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