V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

@inproceedings{MeoEvoli2015VATPaseAM,
  title={V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy},
  author={Nathalie Meo-Evoli and Eug{\`e}nia Almacellas and Francesco Alessandro Massucci and Antonio Gentilella and Santiago Ambrosio and Sara C. Kozma and George Thomas and Albert Tauler},
  booktitle={Oncotarget},
  year={2015}
}
In addition to being a master regulator of cell cycle progression, E2F1 regulates other associated biological processes, including growth and malignancy. Here, we uncover a regulatory network linking E2F1 to lysosomal trafficking and mTORC1 signaling that involves v-ATPase regulation. By immunofluorescence and time-lapse microscopy we found that E2F1 induces the movement of lysosomes to the cell periphery, and that this process is essential for E2F1-induced mTORC1 activation and repression of… CONTINUE READING
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