V-1 regulates capping protein activity in vivo.

  title={V-1 regulates capping protein activity in vivo.},
  author={Goeh Jung and Christopher J Alexander and Xufeng Wu and Grzegorz Piszczek and Bi-Chang Chen and Eric Betzig and John A Hammer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 43},
Capping Protein (CP) plays a central role in the creation of the Arp2/3-generated branched actin networks comprising lamellipodia and pseudopodia by virtue of its ability to cap the actin filament barbed end, which promotes Arp2/3-dependent filament nucleation and optimal branching. The highly conserved protein V-1/Myotrophin binds CP tightly in vitro to render it incapable of binding the barbed end. Here we addressed the physiological significance of this CP antagonist in Dictyostelium, which… CONTINUE READING