V(H) gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice.

@article{Bertrand1998VHGR,
  title={V(H) gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice.},
  author={Fred E. Bertrand and Rachel Golub and G. E. Wu},
  journal={European journal of immunology},
  year={1998},
  volume={28 10},
  pages={3362-70}
}
Genes encoding the heavy chain portion of immunoglobulin molecules arise from the combinatorial association of V, D and J gene segments, which occurs during discrete stages of B lineage development in the bone marrow. Recently, V(H) replacement, a form of receptor editing, has been described, in which the variable region of an existing VDJ(H) rearrangement is replaced by another V(H) gene segment in a recombination event believed to involve an embedded heptamer within the coding region of the V… CONTINUE READING

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