V(D)J recombination and the transgenic brain blues.

@article{Schatz1992VDJRA,
  title={V(D)J recombination and the transgenic brain blues.},
  author={David G Schatz and Jang-Ho Chun},
  journal={The New biologist},
  year={1992},
  volume={4 3},
  pages={
          188-96
        }
}
The existence of somatic, site-specific recombination in the central nervous system (CNS) has long been hypothesized but has been difficult to investigate experimentally. The finding that RAG-1, which is thought to encode a component of the site-specific recombination machinery of the immune system, is transcribed in the central nervous system (J.J.M. Chun et al., 1991, Cell 64:189-200), has renewed interest in this issue. Two groups (M. Kawaichi et al., 1991, J Biol Chem 266:18,376-18,394; M… CONTINUE READING