V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining

@article{SoulasSprauel2007VDJAI,
  title={V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining},
  author={Pauline Soulas-Sprauel and Paola Rivera-Mu{\~n}oz and Laurent Malivert and G Le Guyader and Vincent Abramowski and Patrick Revy and J-P de Villartay},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={7780-7791}
}
The immune system is the site of intense DNA damage/modification, which occur during the development and maturation of B and T lymphocytes. V(D)J recombination is initiated by the Rag1 and Rag2 proteins and the formation of a DNA double-strand break (DNA dsb). This DNA lesion is repaired through the use of the non-homologous end-joining (NHEJ) pathway, several factors of which have been identified through the survey of immunodeficient conditions in humans and mice. Upon antigenic recognition in… CONTINUE READING
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