UvrD controls the access of recombination proteins to blocked replication forks.

  title={UvrD controls the access of recombination proteins to blocked replication forks.},
  author={Roxane Lestini and B{\'e}n{\'e}dicte Michel},
  journal={The EMBO journal},
  volume={26 16},
Blocked replication forks often need to be processed by recombination proteins prior to replication restart. In Escherichia coli, the UvrD repair helicase was recently shown to act at inactivated replication forks, where it counteracts a deleterious action of RecA. Using two mutants affected for different subunits of the polymerase III holoenzyme (Pol IIIh), we show here that the anti-RecA action of UvrD at blocked forks reflects two different activities of this enzyme. A defective UvrD mutant… CONTINUE READING
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