Uveal melanoma cell lines depend on multiple signaling pathways for survival

  title={Uveal melanoma cell lines depend on multiple signaling pathways for survival},
  author={John J Park and Ashleigh Jacqueline Stewart and Mal Irvine and Bernadette Pedersen and Richard F. Kefford and Russell J. Diefenbach and Matteo S Carlino and Helen Rizos},
  journal={Annals of Oncology},
Abstract Background Uveal melanoma (UM) is a rare cancer that arises from melanocytes in the uveal tract of the eye. Despite effective treatment for primary UM, > 50% of patients develop metastatic disease. There is currently no effective treatment for metastatic UM and median life expectancy is  Methods The response 11 UM cell lines to 6 selective inhibitors was investigated using cell viability assays and cell cycle analyses by flow cytometry. Inhibition of selected pathways was examined… 
Hindsight: Review of Preclinical Disease Models for the Development of New Treatments for Uveal Melanoma
A retrospective view of the existing preclinical models used to study uveal melanoma and their strengths and limitations is provided, and the gap in the translation of preclinical findings to human studies is evaluated.