Uveal melanoma cell lines contain stem-like cells that self-renew, produce differentiated progeny, and survive chemotherapy.

Abstract

PURPOSE Uveal melanoma (UM) cells in high-metastatic risk tumors have an undifferentiated molecular signature indicative of a more primitive cellular phenotype. Given mounting evidence for the existence of cancer stem cells (CSC), the authors investigated whether UM cell lines retain a population of self-renewing tumorigenic cells. METHODS Single-cell… (More)
DOI: 10.1167/iovs.11-7379

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Cite this paper

@article{Kalirai2011UvealMC, title={Uveal melanoma cell lines contain stem-like cells that self-renew, produce differentiated progeny, and survive chemotherapy.}, author={Helen Kalirai and Bertil E. Damato and Sarah E Coupland}, journal={Investigative ophthalmology & visual science}, year={2011}, volume={52 11}, pages={8458-66} }