PURPOSE To describe the first reported cases of uveal effusion syndrome following laser in situ keratomileusis (LASIK). DESIGN Interventional case reports. METHODS A 50-year-old woman developed bilateral submacular choroidal folds with subtle fluid elevation of the macula on the first day following uneventful LASIK for hypermetropia. A 48-year-old man developed right, prominent, 360-degree, peripheral choroidal effusions and submacular choroidal and retinal folds several months following LASIK for hypermetropia. RESULTS Case 1 was treated with systemic diclofenac and case 2 with systemic prednisolone. Both cases showed gradual improvement in vision over several weeks, returning to best-corrected visual acuity of 6/6. CONCLUSIONS Uveal effusion syndrome is a previously unreported complication that may occur following LASIK for hypermetropia.