Uv-spectrophotometric and Rp-hplc Methods for the Simultaneous Estimation of Acetaminophen and Caffeine: Validation, Comparison and Application for Marketed Tablet Analysis


In the present study UV-spectrophotometric and RP-HPLC methods were validated for the simultaneous analysis of acetaminophen and caffeine in marketed tablets. The methods were validated in terms of linearity, accuracy (% Recovery), precision (inter day, intra day and reproducibility) and robustness. Both the methods were linear (R 2 = 0.998-0.999) and… (More)


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