Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice

@inproceedings{Piette2018UtrophinHD,
  title={Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice},
  author={Antoine Boulanger Piette and Dounia Hamoudi and Laetitia Marcadet and Fr{\'e}d{\'e}rique Kyomi Labelle and Rares Ovidiu David and Sabrina Boss{\'e} and Anteneh Argaw and Jĕr{\^o}me Frenette},
  booktitle={PloS one},
  year={2018}
}
The lack of dystrophin in Duchenne muscular dystrophy (DMD) compromises the integrity and function of muscle fibers. Skeletal muscles, except the diaphragm, do not undergo progressive degeneration in adult mdx mice due to compensatory mechanisms, including structural protein upregulation. New mouse models, including utrophin haploinsufficient mdx (mdx/utrn+/-) mice, may better recapitulate DMD. Our goal was to determine whether mdx/utrn+/- worsens the mdx phenotype and to characterize the… CONTINUE READING
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