Utrophin: a structural and functional comparison to dystrophin.

  title={Utrophin: a structural and functional comparison to dystrophin.},
  author={Derek J Blake and Jonathon M. Tinsley and K. E. Davies},
  journal={Brain pathology},
  volume={6 1},
Utrophin is an autosomally-encoded homologue of dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene. Although, utrophin is very similar in sequence to dystrophin and possesses many of the protein-binding properties ascribed to dystrophin, both proteins are expressed in an apparently reciprocal manner and may be coordinately regulated. In normal skeletal muscle, utrophin is found at the neuromuscular junction (NMJ) whereas dystrophin predominates at the sarcolemma… CONTINUE READING
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