Utiliztion of the Suzuki Coupling to Enhance the Antituberculosis Activity of Aryl Oxazoles.

Abstract

Potent antituberculosis aryl oxazoles can be made in an efficient three step process--formation of β-hydroxy amides with serine benzyl ester; cyclization to afford oxazolines; and then dehydration to give the corresponding oxazoles. Furthermore, incorporation of an appropriate aryl halide allows utilization of the Suzuki cross coupling reaction to access… (More)

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