Utilizing uncertainty factors in minimal risk levels derivation.

  title={Utilizing uncertainty factors in minimal risk levels derivation.},
  author={Hana R. Pohl and Henry G. Abadin},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={22 2},
The Agency for Toxic Substances and Disease Registry (ATSDR) utilizes chemical-specific minimal risk levels (MRLs) to assist in evaluating public health risks associated with exposure to hazardous substances. During MRL derivation, uncertainty factors (UF) are used. Under current ATSDR methodology, default UFs of 10 are applied to extrapolate from a lowest-observed-adverse-effect level (LOAEL) to a no-observed-adverse-effect level (NOAEL), for interspecies extrapolation and for intraspecies… CONTINUE READING