Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.

  title={Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.},
  author={Jonathan D. Silk and Ian F Hermans and Uzi Gileadi and Tsung Wen Chong and Dawn Shepherd and Mariolina Salio and Bini Mathew and Richard R Schmidt and Sarah Jane Lunt and Kaye J. Williams and Ian James Stratford and Adrian L. Harris and Vincenzo Cerundolo},
  journal={The Journal of clinical investigation},
  volume={114 12},
Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration of the glycolipid ligand alpha-galactosylceramide (alpha-GalCer) or the sphingosine-truncated alpha-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and gamma interferons that contribute to DC maturation. This process enhances T cell immunity to antigens presented by the DC. The adjuvant activity is further amplified if APCs are stimulated through… CONTINUE READING
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Therapeutic activation of Vα24+Vβ11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity

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