Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma.

@article{Hsiao2013UtilizingST,
  title={Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma.},
  author={Tzu-Hung Hsiao and Hung-I Harry Chen and Jo-Yang Lu and Pei-ying Lin and Charles Keller and Sarah A. Comerford and Gail E. Tomlinson and Yidong Chen},
  journal={Translational cancer research},
  year={2013},
  volume={2 1},
  pages={
          6-17
        }
}
Extracting maximal information from gene signature sets (GSSs) via microarray-based transcriptional profiling involves assigning function to up and down regulated genes. Here we present a novel sample scoring method called Signature-score (S-score) which can be used to quantify the expression pattern of tumor samples from previously identified gene signature sets. A simulation result demonstrated an improved accuracy and robustness by S-score method comparing with other scoring methods. By… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2011

A pathway-based classification of human breast cancer.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010

Molecular mechanisms of cholangiocarcinoma.

  • World journal of gastrointestinal pathophysiology
  • 2010

Similar Papers

Loading similar papers…