Utilizing relative potency factors (RPF) and threshold of toxicological concern (TTC) concepts to assess hazard and human risk assessment profiles of environmental metabolites: a case study.

@article{Terry2015UtilizingRP,
  title={Utilizing relative potency factors (RPF) and threshold of toxicological concern (TTC) concepts to assess hazard and human risk assessment profiles of environmental metabolites: a case study.},
  author={C Chilcott Terry and Reza J. Rasoulpour and Steve Knowles and Richard Billington},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2015},
  volume={71 2},
  pages={
          301-17
        }
}
There is currently no standard paradigm for hazard and human risk assessment of environmental metabolites for agrochemicals. Using an actual case study, solutions to challenges faced are described and used to propose a generic concept to address risk posed by metabolites to human safety. A novel approach - built on the foundation of predicted human exposures to metabolites in various compartments (such as food and water), the threshold of toxicological concern (TTC) and the concept of… CONTINUE READING
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